Pospisil lost to Andy Murray in three sets of their quarter-final match on a wet Wednesday, with the Canadian going out 6-4, 7-5, 6-4 after an exhausting 10 days of grass-court tennis.
"I played a lot of tennis, how much that affected the match is hard to say," said Pospisil. "But I definitely started feeling a little bit heavy, especially that third set.
"I played, I don't know, 31 sets in seven days or something like that. Then you're going to play Andy, who plays long rallies. Obviously I would have liked to have been more fresh, but it's still been a great week, just the beginning."
Pospisil, stretched to five sets in three of his five singles matches, began feeling his legs against Murray. Pospisil and American partner Jack Sock were defeated last week as they defended their 2014 doubles title, only adding to Pospisil's workload.
The Centre Court contest against third seed Murray began with the roof open but after a second rain interruption, concluded after two hours 11 minutes with the translucent structure closed
Pospisil had hoped to join Robert Powell (1908 Wimbledon) and Milos Raonic (2014 Wimbledon) as the only Canadian men to make a Grand Slam final four. He was dismayed after being warned in mid-serve on a time violation, late in the seconds set as he dropped serve 5-6.
A nagging injury also bothered Pospisil, who said he needs to get a scan on an undefined problem in his right hand which he has been feeling for a few days. But he immediately said he did not expect it to keep him from playing for Canada against Belgium in the Davis Cup next weekend.
"I'm not expecting it to be anything serious," said Pospisil. "The plan right now is 100 per cent to go play, unless the get show something I'm not expecting it to show. It's just a precautionary MRI, so I'll see."
Pospisil ended with nine aces but only one break point chance, which Murray saved. Pospisil fired 34 winners in his losing effort.
The 56th-ranked Pospisil suffered his fourth loss in less than a year to Murray as the pair met on grass for the first time.
Pospisil and his seeded opponent had to put up with a 35-minute weather interruption with Murray leading 3-1 in the first set and again left the court with Pospisil up 4-3 in the second set. At that point, the roof was closed to allow play to conclude.
Murray profited from a break for 6-5 in a game where Pospisil was warned for taking more than 20 seconds between points. Murray took a 2-0 lead on sets a game later when Pospisil netted a service return.
Murray earned the deciding third-set break in the ninth game as he easily returned a cross-court winner off of a Pospisil shot from the back of the court.
The 2013 Wimbledon champion served out the victory a game later to end Pospisil's tournament on a second match point with a cross-court winner.