Eight other people are recovering from injuries after a minivan and a sport utility vehicle collided late Sunday morning at a highway intersection near Alix, about 160 kilometres south of Edmonton.
RCMP say the 37-year-old father died at the scene, while the infant died in a Calgary hospital.
The baby's mother and two boys, ages 10 and four, were hurt, as were five people in the SUV.
The names of the victims have not been released.
Mounties say charges are pending.