West will join Miami rapper Pitbull and Toronto-born Serena Ryder in a televised performance for the July 26 closing ceremony.
West has been rumoured to be set for the Pan Am closing event since basketball player Anthony Bennett tweeted the news on Wednesday.
West played the Ottawa Bluesfest earlier in July, despite a petition to get him off the bill for the festival.
West has also made appearances at Toronto's OVO Festival, organized by local rap star Drake. This year's event is Aug. 1-3 in Toronto.