Here's what you need to know:
1. 100-metre final
Once again, all eyes Wednesday will be on 20-year-old Andre De Grasse, from Markham, Ont., as he goes for gold in the premier event of the Pan Ams: the men's 100m. De Grasse, the reigning NCAA champion in the 100m and 200m, is a good bet to make it through the semifinals and reach the podium in the finals, which start at 8:50 p.m. ET. The races will be live on CBC TV (Ontario east) and livestreamed on cbc.ca/panam.
Canada's Jessica Smith and Melissa Bishop will compete in the women's 800m final, while Damian Warner will start his quest for gold on the first day of the decathlon. Warner, 25, is the gold medal favourite in the event. All of the action begins at 10:05 a.m. ET.
2. Field hockey final four
Canada's field hockey women will look to advance to the gold medal match as they take on the U.S. in a crucial semifinal at 7:30 p.m. ET. However, they will be in tough as the Americans haven't allowed a goal in the tournament, having out-scored their opponent's 34-0 en route to a perfect 4-0 record.
Canada has three wins and one loss, including a clean sheet quarter-final win over Uruguay on Monday night. Argentina and Chile will battle it out in the other semifinal match. The winner of the tournament earns themselves a spot in the 2016 Summer Olympic Games in Rio de Janeiro, Brazil.
3. Semifinal soccer
The Canadian women's soccer team will have a chance to put a tough preliminary round behind them by beating Colombia in the semifinal at 8:35 p.m. ET. Canada has one win and two losses entering the semi and will face a Colombia squad that has two wins and a tie. Canada has been out-scored by their opposition 5-2, while Colombia has out-scored their opponents 4-1. Prior to this tilt, Brazil and Mexico will battle it out in the other semifinal. The winners of Wednesday's games will battle it out for gold Saturday at 6:30 p.m. ET.
4. McClintock goes for gold
Canada's Whitney McClintock will be a gold medal favourite in the overall competition of the water-ski finals, which begins at 10:25 a.m. ET at the Ontario Place West Channel.
McClintock is a five-time world champion. Jaret Llewellyn will represent Canada in the men's overall competition which takes place prior to the women's event. Finally, Rusty Malinoski will be the lone Canadian in the men's wakeboard final, starting at 4:00 p.m. ET.