The Canada Border Services Agency said a truck was flagged for a secondary inspection at the Ambassador Bridge crossing on Monday. The bridge connects Windsor, Ont. and Detroit, Mich.
The CBSA said its officers found the suspected cocaine hidden inside three duffel bags and a tote container, all of which were allegedly hidden in the truck's storage areas.
The drugs were seized, the RCMP were called in and charges were laid.
The 26-year-old man faces charges of cocaine importation and possession of cocaine for the purposes of trafficking.
The accused is due to appear in a Windsor court on Tuesday. The charges have not been proven in court.
The CBSA says it has seized some 302 kilograms of cocaine in its southern region over the past year and a half.