Sgt. Audrey-Anne Bilodeau of the Quebec provincial police said two or three others have serious and life-threatening injuries.
The three-car crash happened around 8:45 p.m. Saturday on the Jean-Jacques Bertrand Bridge, on Route 202.
Route 202 between Route 223 and Bord de l'eau Road remains closed.
"The bridge is still closed because the guardrail is damaged," Bilodeau said.
Police are investigating the circumstances of the crash.