The victims of the shooting are a young woman, who was pronounced dead on the scene, and a man who died in hospital.
They died in what police described as a "sporadic" shooting with three separate crime scenes in the area in and around the club. The shooting happened at 3:30 a.m.
The club was hosting an event believed to be an after party for OVO Fest, an annual event at the nearby Molson Amphitheatre hosted by Toronto rapper Drake.
One woman showed up at hospital after the shooting with a minor gunshot wound to the leg.
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