The role of genetics in identifying women at high riskElisabeth Baugh, CEO of Ovarian Cancer Canada Since Angelina Jolie-Pitt went public about her preventive surgery to reduce risk of ovarian and breast cancers, there has been a spike in awareness about the impact of genetics on a person's overall likelihood of developing cancer.
- Ovarian cancer is the most fatal of all women's cancers in Canada
- All women are at risk - some more than others
With the highest mortality rate of all female cancers, ovarian cancer claims the lives of 1,750 Canadian women every year. In Canada, approximately 2,800 women are diagnosed annually. Yet there is no reliable screening test or vaccine for this disease.
Because its symptoms are so often confused with those of less serious conditions, ovarian cancer is usually detected at a late stage. Typically, treatment starts when the cancer has already spread. This leads to a devastating mortality rate with more than half of women dying within five years of a diagnosis.
Research shows relying on symptoms to detect ovarian cancer simply isn't reasonable. With symptoms that are often confused with other health issues, the disease is easily overlooked, making genetic testing that much more important for those at high risk.
You may be at higher risk for ovarian cancer if you:
- Are 50 years of age or older
- Have a family history of ovarian, breast, endometrial or colorectal cancer
- Are of Ashkenazi Jewish descent
- Have a hereditary predisposition, such as a BRCA gene mutation, which is associated with ovarian cancer
If you have a family history of breast or ovarian cancer, genetic counselling and testing can help identify if you have an increased likelihood of developing these diseases.
Your doctor can assist with determining your eligibility for genetic screening, and like Jolie-Pitt, the results may contribute to an informed decision that helps manage your health. Women who test positive for a BRCA1 or BRCA2 gene mutation should talk to their doctor about options that can reduce the risk of cancer.
The following factors reduce the risk of ovarian cancer:
- Use of oral contraceptives
- Full-term pregnancy
- Removal of the ovaries and/or fallopian tubes
- Tubal ligation
Talking to your doctor about possible risk factors and life stage is vital to understanding your best options for prevention.
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