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Hospital wastewater may contain a solution.
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As much as public health officials have tried to slow the progress of antibiotic resistance, the pace has not slowed.
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Some countries are finding cases of the infection that are untreatable by all known antibiotics.
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Several different bacterial and fungal species can be found in cheese and their interactions can be monitored.
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A need exists for rapid change in the social mindset of the next generation on antibiotics. If our youth do not appreciate the challenges facing public health officials today, they may end up living under the shadow of untreatable bacterial infections known as the post-antibiotic era.
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Over the last few years, the human body's microbial population has been the subject of numerous discussions and controversies. But few topics have sparked as much interest as the concept of fecal microbiota transplantation, or FMT. This rather easy procedure has become a lightning rod for debates ranging from its effectiveness to ethical issues regarding donations.
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We are facing an antibiotic resistance crisis. Almost every health authority has sounded the alarm and the most recognized authority, the World Health Organization, is doing all it can to slow the arrival of the post-antibiotic era. Yet, even as these calls are made, the use of these drugs continues to be unacceptably high.
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At its core, antibiotic resistance is merely a coping mechanism. Bacteria are faced with a rather dire form of stress and need to find a way to cope. They can take the biological route of genetic mutation to render the drug useless. They also can gain a plasmid from the environment or another bacterium, to gain resistance mechanisms.
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"We have put substantial efforts to stop its rise, but this is not enough."
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Though infections can affect almost any area of the body, on average, about half of the troubles are gastrointestinal, usually in the form of traveller's diarrhea. While this condition usually is not life-threatening, the symptoms certainly can ruin a vacation. Thankfully, most of these troubles are caused by bacteria and can be treated with a simple antibiotic prescription. Within a few days, the pain and those runs fade away allowing individuals to continue enjoying their trip.
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Lice are an unfortunate part of human existence. These small ectoparasites find their way into the hair and then make a home where they can eat, grow, and reproduce. They are common worldwide and as any parent knows, symptoms are frustrating and treatment is arduous and at times ineffective.
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The concept of tolerance isn't relevant only in the microbial world. All biological life has the ability to tolerate, including humans. A perfect example of this phenomenon occurs in those able to eat hot, spicy foods. You might think they are simply born with stronger tongues. But that isn't the case. Instead, in most cases, a biochemical modification has occurred in one of the proteins found on the tongue.
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It's no secret we are in an antibiotic resistance crisis. Warnings about the looming post-antibiotic era are everywhere and people are being asked to help in whatever way they can. Yet, while we can all work to reduce the amount of antibiotics used in medicine, these achievements represent only a small fraction of the work that needs to be done.
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The mere mention of nanotechnology may raise eyebrows. Yet worries should not be based on size but molecular composition instead. If a particle is made from plastic or heavy metals, concern is definitely valid. However, polylactic acid nanoparticles are biodegradable, making them perfect for use both in the environment and also in the body.
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A few months ago, the discovery of the antibiotic resistance gene mcr-1 sent shockwaves through the public and the health communities. This piece of bacterial DNA, also known as plasmid-mediated colistin resistance, revealed bacteria had developed a mechanism to tolerate yet another antibiotic.
A Finnish group of researchers released the results of a three-year study examining the effects of long-term probiotic use on antibiotics and children's health. The results suggest probiotics may offer far more than a means to prevent AAD and C. difficile. They may actually help to reduce the need for antibiotics in the future.
It's been nearly two years since the World Health Organization called the rise in antibiotic resistance a crisis. Since that time, public health officials have sought new answers to prepare for an uncertain future. While the idea of making new and stronger antibiotics continues to explored, its popularity has faded.
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For many Canadians, no turkey dinner is complete without the addition of cranberry sauce. The tartness from the red berries offers a perfect complement to the rich meal. But beyond these special moments, cranberries have long been thought to be an excellent way to improve health, particularly in the urinary tract.
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"Once they start moving around, then it becomes very, very challenging to contain."
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The World Health Organization has led the charge to raise awareness and ensure the public understands the looming crisis of what is commonly known as the post-antibiotic era. In essence, we may be forced to return to a world in which these life-saving medicines are no longer effective.
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Despite all the technology in academic and pharmaceutical institutions, nothing can stop a microbe from figuring out how to best an antibiotic. As such, the mood is sombre at best and apocalyptic at worst. Instead of trying to develop yet another complex mousetrap, the answer lies in looking at weapons of mass microbial destruction already in use in the wild.
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Do you understand antibiotic resistance?
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The overwhelming majority of these incredibly common infections are caused by viruses -- that is, they will not respond to antibiotics -- so I don't routinely offer antibiotic treatments. When patients hear they won't be getting an antibiotic many become surprised and often upset. I then spend time counselling them about why antibiotics are, in most cases, the wrong treatment choice.
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Last week, much ado was made about a fascinating story coming out of the United Kingdom. A thousand year old remedy for a common eye problem -- styes -- was tested in the lab against the pathogen, Methicillin Resistant Staphylococcus aureus (MRSA). The concoction was not only effective at killing the bacterium but also outperformed a common antibiotic, vancomycin.
One of the best places to look for alternatives is nature. Antibiotics were first discovered in natural species -- fungi to be exact -- and a number of options for the future have been found. Now it seems there is another possible option worth exploring: turmeric.
One of the primary goals in understanding how the bacterium used its toxin to cause disease focused on the nature of bacterial growth in the body. After all, not everyone who was exposed ended up with illness. The first major discoveries revealed the toxin was not produced all the time.
For those studying this unique branch of terrestrial life, the identification of resistance genes in the environment suggested there had to be antimicrobials out there. If this was the case, the Archaea were going to play a role. The only question they couldn't answer was the nature of this role. This past week, a team of researchers from Vanderbilt University may have provided the answer: Horizontal Gene Transfer (HGT).
Antibiotics were the first and still are the go-to means of microbial distraction. However, in light of the continuing rise of antibiotic resistance, their usefulness is limited and we need to explore other options. One such ally is a living organism known to have just as much of a hatred for infectious bacteria: the bacteriophage.
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The results suggested bacteria are continually in communication with one another. When times get dire, they attempt to find anyone who might have resistance and be willing to pass it on. Once there is a yes, a crowd appears, all hoping for the same gift. Once they get it, they head off to do the same.
The unmitigated use of antibiotics in agriculture is pushing humanity into a global public health crisis, a new paper by a University of Calgary professor states. U of C economics professor Aidan Holl...