Support staff at McGill University walked off the job early Thursday morning, launching a general strike on the first day of class for many students.
The school and support staff are at odds over salaries and social benefits.
Moving ahead with a strike means students will be affected, but staff say have no choice, said Patrick Leblanc, a spokesman for the Public Service Alliance of Canada.
Striking staff members were on the picket line at 7 a.m. Thursday.
Several services will be disrupted, including on-campus residences and class laboratories.