The Royal Newfoundland Constabulary said in an email that 10 adult dogs and three puppies were inside the home when it caught fire Tuesday morning. The police force said 11 of the animals have been recovered so far.
The force declined interview requests, saying they would release more information Wednesday.
Supt. Derek Chafe of the St. John's Regional Fire Department said the home, which is located in the neighbourhood of Kilbride, was undergoing renovations and no one was inside at the time of the blaze.
"It took a bit of time to get the fire knocked down due to renovation and debris going on in the home at the time," Chafe said in an interview.
He said he didn't know why there were so many dogs inside the home.
The cause of the fire is still under investigation.