The point guard received a standing ovation and waved to the crowd as he limped onto the court to present the game ball, then watched from a suite as the 76ers outscored Chicago 36-14 in the third quarter to take an 83-69 lead.
Game 3 is Friday in Philadelphia.
Holiday was 11 of 15 from the field, and the Sixers shot 59 per cent overall. Evan Turner chipped in with 19 points, seven rebounds and six assists.
Joakim Noah led the Bulls with 21 points and eight rebounds and John Lucas III scored 15 points.
Rose missed 27 games during the regular season because of a variety of injuries, and the Bulls went 18-9 in those games.
CELTICS 87, HAWKS 80
ATLANTA (AP) — Paul Pierce had 36 points and 14 rebounds and Boston wiped out Atlanta's 11-point lead in the second half even without point guard Rajon Rondo.
The series is tied 1-1. Game 3 is Friday night in Boston, and Rondo will be back for that one having sat out a one-game suspension for bumping an official in the opener.
The Hawks took a 65-54 lead late in the third quarter. But Boston sliced it to 66-61 by the end of the period. Pierce hit his first three-pointer of the series after missing 10 to stretch the lead to 79-72 with 3 1/2 minutes left.
Pierce finished 12 of 26 from the field and dropped to his knee and Tebowed after a free throw that locked it up with just a minute to go.
Kevin Garnett had 15 points and 12 rebounds for Boston.
Joe Johnson had 22 points for Atlanta.
LAKERS 104, NUGGETS 100
LOS ANGELES (AP) — Kobe Bryant scored 38 points and Andrew Bynum followed up his playoff-opening triple-double with 27 points and nine rebounds, as Los Angeles took a 2-0 series lead.
Pau Gasol had 13 points, 10 rebounds and five assists for the Lakers, who still haven't trailed in this series despite nearly crumbling against a much-improved effort by the Nuggets and Ty Lawson, who scored 25 points and led the fourth-quarter charge.
Los Angeles' 19-point lead in the third quarter dwindled to four with three minutes to play, but Ramon Sessions scored four key points in the final 1:14 before Bryant's icing free throws with 9.4 seconds left.
Game 3 is Friday in Denver.
The Nuggets lost their ninth straight road playoff game.
Sessions scored 14 points for Los Angeles.
Kenneth Faried had 14 points and 10 rebounds while Danilo Gallinari and Corey Brewer added 13 points apiece for Denver.