The Federal Court of Appeal sided with the federal government on Tuesday.
It overturned a lower court ruling that said Agriculture Minister Gerry Ritz broke the law when he stripped the wheat board of its monopoly over western wheat and barley sales.
The lower court had sided with former wheat board directors, who argued the law required the government to hold a plebiscite among farmers before making any changes.
The federal Appeal Court ruled there is nothing to prevent the government from changing its own law in Parliament.
Stewart Wells, chairman of the Friends of the Canadian Wheat Board, says the group will continue with a class-action lawsuit asking the court to restore the board and give farmers $17 billion in damages.