The Blue Jays slugger blasted a three-run shot for his major-league leading 26th home run of the season Thursday, but Cecil couldn't hold the lead as the Los Angeles Angels hung on to defeat Toronto 9-7.
"I feel bad personally because the guys go out there and bust their butts to get some runs for me and I've got to go out and have a shut down inning," said Cecil (1-1), who allowed 10 hits, eight runs and three home runs in 5 1-3 innings of work. "Especially after Jose gets a three-run bomb, that's when I've got to go back out and shut the door and get them back in quick so they can get more runs.
"That's what I probably feel worst about."
After Bautista gave Toronto a lead 6-5 lead in the bottom of the sixth with his 14th home run in June, a club record for any month, the Angels regained the lead in the sixth.
Erick Aybar bunted and reached second on Cecil's throwing error before Peter Bourjos doubled to tie the game. Mike Trout then stepped up and hit his eighth homer of the season to end Cecil's night.
"At some point we've got to find a way to get deeper into games," said Blue Jays manager John Farrell, whose starting staff has been ravaged by injuries. "We're putting an awful lot of pressure on our bullpen right now. That goes without saying. But it's not only encouraging but it's impressive the way our guys continue to swing the bat night in and night out."
Mark Trumbo had a home run and a triple, Alberto Callaspo also went deep and Albert Pujols had four hits, including two doubles, and scored three runs for the Angels in the opener of a four-game series.
Blue Jays catcher Jeff Mathis equalled a career-high with four hits, including a home run against his former team, but all he could think about was Toronto's pitching woes.
"Obviously it's nice to have a day at the plate like that but when you come out with a loss it's still not satisfying," Mathis said. "It was a nice day offensively but we need to get it down defensively behind the plate too."
Mathis' fourth hit of the game, a single, led off the ninth as the Blue Jays went on to load the bases against Ernesto Frieri, but the Angels closer induced a double play from Edwin Encarnacion to end the threat and collect his 10th save of the season.
Angels' right-hander Dan Haren (6-7) allowed six runs on seven hits over six innings, including both Toronto homers.
Callaspo gave the Angels (43-33) a 1-0 lead with two outs in the second with his fifth home run of the season.
The Blue Jays (38-38) tied it in the bottom of the inning. Encarnacion led off with a walk, took third when Kelly Johnson ended a 0-for-13 drought with a double and came home on Yunel Escobar's grounder to short.
Mathis led off the third with his fourth homer of the season.
The Angels scored three in the fourth, two on Trumbo's 19th homer of the season that followed a leadoff double by Pujols.
Howie Kendrick then walked, took second on Callaspo's single and after a sacrifice bunt by Aybar, scored on Bourjos' sacrifice fly.
The Blue Jays got one back in the home fourth on a sacrifice fly by Rajai Davis that score Encarnacion from third.
Pujols doubled and scored on a single by Kendrick to put the Angels into a 5-3 lead in the top of the fifth.
"When (Cecil) left a pitch up over the plate, they didn't miss it," Farrell said. "There were periods within the five-plus innings that he pitched that he did get the ball down. I thought early in the game he established his secondary stuff well and he kept some guys off-balance but as the game wore on through the middle innings when he made a mistake up it cost him."
The Angels, who have won 25 of their past 33 games, are 14-1 in their past 15 road games and 17-7 in June.
"If we're going to reach our goal, our lineup has to flow like this," Angels manager Mike Scioscia said. "Obviously Mike (Trout) is a huge catalyst at the top of the order. These guys are all chipping in and doing what they can do."
LaTroy Hawkins replaced Haren in the seventh and allowed a run on a double by Mathis and a single by Brett Lawrie to make it 8-7.
The Blue Jays had a chance to tie in later in the inning but Colby Rasmus was thrown out at home on Bautista's grounder to short with the infield drawn in.
After Pujols led off the ninth with a single against Casey Janssen, Trumbo, who finished with three RBIs, tripled him home to make it 9-7.
Notes: Attendance at Rogers Centre was 24,668. ... Right-hander Henderson Alvarez did some long-toss Thursday and appears on schedule to make his start Saturday. He left his win in Boston on Monday with stiffness in his elbow but was cleared to pitch after an MRI on Tuesday. ... Carlos Villanueva (2-0, 3.24 ERA) makes his first start of the season Friday against the Angels' Erwin Santana (4-6, 4.92 ERA).