Amir Remtulla, who replaced Ford's campaign manager Nick Kouvalis in February last year, is leaving July 20 to take a job with the 2015 Pan Am Games.
"Amir has brought tremendous leadership to my team," Ford said in a statement. "His experience, advice and dedication to his work will be missed. I would like to thank him for his service and helping move a number of major accomplishments through council. I wish him all the best in his new role."
Remtulla said in a statement that he was proud to serve for Ford.
"As a result, Toronto taxpayers now know that their dollars are being spent wisely and that customer service is improving," he said.