RCMP Sgt. Paul Reshaur said the crash happened just before 1 a.m. PT at the intersection of 88th Avenue and 150th Street.
Reshaur said the motorcyclist was travelling "at a fairly high rate of speed" when it slammed into the back of a Mitsubishi.
"As a result of the collision, the 48-year-old man was killed and the motorcycle skidded almost a full block," Reshaur said.
The woman driving the Mitsubishi was shaken but not injured.
"We’re investigating, of course, all factors but at this point we believe speed is a factor," Reshaur said.
"We don’t believe alcohol or drugs at this point are [factors], but it is still at the early stages of the investigation."
The victim’s name has not been released.