Mike Trout had two hits, giving him 139 in the first 100 games of his rookie season, the most since 1964 when Tony Oliva had 144 for Minnesota. But his streak of 30 successful stolen base attempts ended in the eighth when Jarrod Saltalamacchia threw him out at second base on a pitchout.
Santana (7-10) allowed two runs on five hits with four strikeouts and two walks, leaving after throwing 100 pitches.
Ernesto Frieri pitched the ninth for his 15th save in 16 opportunities.
Aaron Cook (3-7) was touched for five runs on 11 hits in five innings and fell to 1-6 in his last eight starts.
WHITE SOX 7, YANKEES 3
CHICAGO (AP) — Kevin Youkilis hit a grand slam, Paul Konerko homered and Dewayne Wise had four hits as the White Sox rallied for the second straight game to beat the Yankees.
Wise, designated for assignment by the Yankees in July, had four singles from the leadoff spot and has played well while filling in for the injured Alejandro De Aza.
With the game tied 2-2, the White Sox loaded the bases in the fifth inning on Alexei Ramirez's double, a walk and single by Wise. Youkilis connected off Ivan Nova (11-7) for his second grand slam at U.S. Cellular Field this season.
Chicago's Francisco Liriano (5-10) also went six innings, surrendering Derek Jeter's leadoff homer and two runs in the first while allowing six hits and three walks.
ROYALS 1, RAYS 0, 10 INNINGS
ST. PETERSBURG, Fla. (AP) — Eric Hosmer's two-out single in the 10th inning lifted Kansas City to a 1-0 victory over Tampa Bay in a classic pitchers' duel between the Royals' Luke Hochevar and the Rays' David Price.
The run off Joel Peralta (1-5) was unearned after an error on Tampa Bay shortstop Ben Zobrist. Kelvin Herrera (1-1) got the win and Greg Holland pitched the 10th inning for his sixth save.
Price and Hochevar both pitched eight innings, giving up a combined four hits.
Hochevar, the first overall pick in the 2006 amateur draft, gave up one hit and struck out 10.
Price, the first overall draft pick in 2007, gave up three hits and struck out eight.
TIGERS 5, BLUE JAYS 3
DETROIT (AP) — Max Scherzer struck out eight in seven impressive innings, and the Tigers took advantage of Ricky Romero's wildness in a victory over Toronto.
Romero (8-11) lost his 10th straight decision, allowing five runs, seven hits and eight walks in 5 1-3 innings. He didn't strike out a batter.
Austin Jackson had three hits, and Scherzer (13-6) was sharp for the Tigers. Scherzer allowed five hits, including Edwin Encarnacion's solo homer. He walked two.
ORIOLES 5, RANGERS 3
ARLINGTON, Texas (AP) — Nate McLouth's two-run homer keyed Baltimore's four-run fifth inning and the Orioles held off the Texas Rangers.
Chris Tillman (6-2) gave up three runs on six hits and struck out seven and walked one in 6 2-3 innings before giving way to the Orioles' bullpen, which now has a 1.57 ERA in the last 18 games. Jim Johnson worked a scoreless ninth to pick up his 38th save.
Manny Machado had a run-scoring triple and J.J. Hardy also drove in a run with a double in the fifth against Scott Feldman (6-9).
The Rangers scored two on Geovany Soto's two-run homer in the seventh inning to pull to 5-3 and then put the tying run on base, but Pedro Strop struck out Josh Hamilton on a slider to end the threat.
ATHLETICS 4, TWINS 1
OAKLAND, Calif. (AP) — Oakland left-hander Brett Anderson pitched seven innings in his first start since undergoing elbow surgery nearly 15 months ago and the Athletics turned a triple play behind him in a 4-1 win over the Minnesota Twins on Tuesday night.
Newly acquired shortstop Stephen Drew went hitless in his Oakland debut but it hardly mattered. Coco Crisp, Seth Smith and Josh Donaldson had two hits apiece for the A's, who remain one-half game behind Baltimore for the second wild-card spot in the American League.
Anderson struck out seven and faced one batter over the minimum in his return after being sidelined since June 5, 2011. He was activated off the disabled list Monday following a six-start rehab stint in the minors.
Ben Revere singled and scored the lone run for Minnesota.
Drew didn't get a hit in four at-bats, extending his slump to 0 for 19. It's the second-longest drought of the veteran infielder's career.
That didn't slow down the A's, who won for the fifth time in six games to even their season series with the Twins.
MARINERS 5, INDIANS 1
SEATTLE (AP) — Felix Hernandez wasn't perfect. He was still dominant.
Hernandez allowed one run in 7 2/3 innings in the first start following his perfect game, Jesus Montero hit a three-run homer in Seattle's four-run seventh inning, and the Mariners won their seventh straight, beating the Cleveland Indians 5-1 on Tuesday night.
Greeted by a crowd of more than 39,000, most of them in yellow shirts with the words "King of Perfection" honouring his perfect game, Hernandez (12-5) gave up a leadoff single to Jason Kipnis on a 0-2 pitch. He allowed seven hits and struck out five.
Cleveland starter Roberto Hernandez (0-2) didn't allow a hit until Eric Thames' homer with two outs in the fifth. John Jaso later broke a 1-1 tie with an RBI double in the seventh and was followed by Montero's 13th homer of the season.
Seattle has won 14 of 15 at home and Felix Hernandez improved to 8-0 with a 1.53 ERA over his last 13 starts. He left to a long ovation with two outs in the eighth after throwing 105 pitches.