Officials at St. Joseph's Healthcare said Thursday the hospital's Charlton campus is no longer grappling with an outbreak of the intestinal bug.
Sixteen patients contracted the infection in hospital over the course of the outbreak declared late last month.
Hamilton General Hospital has also been fighting an outbreak of the bacteria on its surgical trauma unit.
Officials there say they'll determine today whether the infection has been brought under control.
C. difficile, which causes diarrhea, is one of the most common infections in hospitals and long-term care facilities.