They also lost slugger Jose Bautista — again — for at least 15 days and perhaps for the rest of the season.
Bautista left Saturday night's game against the Baltimore Orioles in the third inning, and after the 8-2 defeat the Blue Jays put him on the 15-day disabled list.
Bautista complained of discomfort in his left wrist, essentially the same injury that put him on the DL for 5 1/2 weeks before his short-lived return on Friday night.
"I've been playing with it and I've been fine. That's why it is a little bizarre to me," Bautista said. "Maybe it's one of those swings I took today. I think I did the proper thing telling them. Doctor says it's nothing to panic about."
Manager John Farrell said Bautista, the reigning two-time AL home run champion, will see a hand specialist on Sunday.
Toronto also put first baseman David Cooper (back strain) on the DL, activated Adam Lind (back) from the disabled list and recalled infielder Adeiny Hechavarria from Triple-A Las Vegas.
The Blue Jays fell 14 games under .500 (56-70) for the first time since Sept. 25, 2009 (70-84). By dropping the first two games of the three-game set, Toronto has lost six straight series.
Edwin Encarnacion hit his 34th home run in the Blue Jays' season-high eighth straight defeat on the road.
Pitching in the majors for the first time since June 11 following a stint on the disabled list with an oblique strain, Toronto starter Brandon Morrow (7-5) allowed four runs, two earned, and six hits in 4 2-3 innings.
"I felt good, I felt strong. It felt pretty good," Morrow said. "I fell behind some counts and put them in a few counts. Couple of defensive mistakes, including myself. You know what? It was all right."
J.J. Hardy homered and scored three runs and rookie Steve Johnson allowed four hits over six innings for the Orioles, who have won 14 of 20.
Hardy, Adam Jones and Matt Wieters each had two RBIs for the Orioles (69-57), who are in the thick of the AL wild-card chase and only four games out of first place in the AL East after going 69-93 in 2011.
Jones, whose two-run single in the fifth inning put the Orioles ahead for good, said "the 69 wins is a product of playing good baseball and competitive baseball on a daily basis. We've got 36 games to go. Let's see our record after 36 games."
Johnson (2-0) gave up two runs, struck out seven and walked two in his second big-league start. The right-hander has 23 strikeouts over 17 innings in five appearances.
"I can't really explain it," he said of his strikeout total.
Toronto bolted to a 2-0 lead in the first. After Mike McCoy was thrown out trying to steal, Bautista drew a two-out walk and Encarnacion hit a 2-2 pitch into the left-field seats — his third homer in five games and fifth over a 12-game span.
Morrow struck out three of the first five batters he faced before the Orioles loaded the bases with two outs in the second for rookie Manny Machado, who struck out.
Baltimore pulled even with two unearned runs in the third. Nick Markakis scored from second when shortstop Yunel Escobar let a potential double-play grounder skip past him, and Wieters followed with a sacrifice fly.
After Jones singled in two runs in the fifth, Hardy hit a two-run drive off Chad Jenkins in the sixth and Wieters added an RBI single for a 7-2 lead.
Machado drove in a seventh-inning run with a single. He had two hits, matching his total over the previous six games.
NOTES: Before the game, RHP Mike Mussina and 2B Rich Dauer were inducted into the Orioles Hall of Fame. ... Slumping Colby Rasmus was supposed to have a day off but entered in the third inning for Bautista. Rasmus went 0 for 3 and has three hits in his last 42 at-bats. ... Wieters threw out three would-be base stealers. It's the 14th time an Orioles catcher has performed the feat, the first since Mickey Tettleton in 1988. ... Escobar doubled in the seventh to end a 7-for-47 skid. It was his second extra-base hit in 22 games. ... Baltimore has been outscored 76-48 in the first inning this season.