The Winnipeg native is being inducted into the Manitoba Sports Hall of Fame.
Hughes competed in winter and summer Olympics as a speedskater and cyclist, winning a total of six medals.
"As one of the greatest Canadian athletes of all time, and the only athlete in the world to win multiple medals in both a summer and winter Olympics, this was an easy decision," hall president Don Pincock said in a release. "Clara has been contributing to our museum collection for a number of years and her induction was just a matter of time."
Hockey Hall of Fame goalie Ed Belfour is also being inducted along with sailor Kelly Hand, speedskater Michael Ireland, football player Harry Langford and softball player Sandy (Newsham) Maskiw.
Longtime administrator Morris Glimcher will be enshrined in the builder's category.
The induction ceremony is set for Nov. 3.