Kyle Quinlan was 24-of-39 passing for 411 yards and three touchdowns Saturday as the defending Vanier Cup champions defeated Windsor 39-18.
Quinlan, who was also intercepted twice, found Max Cameron seven times through the air for 209 yards as No. 1 McMaster improved to 7-0 on the season.
Dahlin Brooks, Spencer Moore and Tyler Loveday caught TDs for the Marauders, while Michael Kashak recovered a fumble in the end zone for another score.
McMaster kicker Tyler Crapigna booted three field goals and added four extra points.
Windsor quarterback Austin Kennedy threw for 350 yards on 24-for-35 passing and two touchdowns but as also intercepted four times.
Evan Pszczonak had four catches for 135 yards and a touchdown for the Lancers, while Dylan Whitfield had the other Windsor TD. Dan Cerino added a field goal and two converts.
Elsewhere in the CIS it was: No. 5 Montreal 23, No. 2 Laval 20; No. 7 Guelph 33, No. 4 Queen's 28; No. 9 Western 56, Laurier 3; No. 10 Acadia 47, St. FX 26; Mount Allison 25, Saint Mary's 12; York 36, Toronto 24; Sherbrooke 40, Bishop's 28; Ottawa 61, Waterloo 0; Concordia 43, McGill 40 and UBC 24, No. 6 Regina 17.
At Hamilton, McMaster's Ben D'Aguilar had one quarterback sack to bring his 2012 total to 12.5, a new CIS single-season record.
The six-foot-two, 240-pound defensive lineman, in his fourth campaign with the Marauders, entered the contest with 11.5 sacks, 0.5 shy of the previous mark established in 1988 by former Bishop's great Leroy Blugh and tied in 1996 by Queen's Jim Aru.
D'Aguilar set the new national standard 90 seconds into the fourth quarter when he tackled Kennedy at the Windsor 20 for a nine-yard loss.
Trailing 11-7 after the first quarter, McMaster took the lead at 7:54 of the second quarter when Quinlan found Brooks for a 12-yard touchdown. Carpigna then booted a 46-yard field goal as time expired in the half to give the Marauders a 17-11 lead at the break.
Another Carpigna field goal and five-yard TD pass from Quinlan to Loveday made it 27-11 with 1:38 left in the third.
Pszczonak got Windsor (3-4) a bit closer on an 80-yard touchdown just 28 seconds later, but Carpigna kicked his third field goal of the game in the fourth before Kashak recovered a fumble in the end zone midway through the quarter.
McMaster added a safety with just under three minutes remaining.
No 5. Carabins 23, No. 3 Rouge et Or 20
At Montreal, Alexandre Nadeau-Piuze threw for 262 yards and two touchdowns as the Carabins (6-1) upset Laval (6-1).
No. 7 Griffins 33, No. 4 Gaels 28
At Guelph, Ont., Robert Farquharson rushed for 87 yards and two TDs as the Griffins (6-1) got past Queen's (5-2).
No. 9 Mustangs 56, Golden Hawks 3
At London, Ont., Will Finch threw for 339 yards and four touchdowns as Western (4-3) hammered Laurier (3-4).
No. 10 Axemen 47, X-Men 26
At Wolfville, N.S., Kyle Graves with three touchdowns on 260 yards passing as Acadia (5-1) defeated St. FX (2-4).
Mounties 25, Huskies 12
At Sackville, N.B., Jordan Botel rushed for 194 yards and a TD as Mount Allison (2-4) defeated Saint Mary's (2-4).
Lions 36, Varsity Blues 24
At Toronto, Kyle Exume rushed for 132 yards and three touchdowns as York (2-5) downed the Varsity Blues (2-5).
Vert et Or 40, Gaiters 28
At Sherbrooke, Que., Jeremi Roch-Doyon threw for 426 yards and three touchdowns as the Vert et Or (4-3) upended Bishop's (3-4).
Gee-Gees 61, Warriors 0
At Ottawa, the Gee-Gees (2-5) beat Waterloo (1-6) for their second straight victory after the firing of head coach Gary Etcheverry.
Stingers 43, Redmen 40
At Montreal, Reid Quest threw for 220 yards and three touchdowns as the Stingers (1-6) held off the Redmen (2-5) for their first win of the season.
Thunderbirds 24, No. 6 Rams 17
At Vancouver, quarterback Billy Greene threw for 190 yards and two touchdowns as UBC (2-4) upset Regina (4-2).