The Wilmington company reported net income of $10 million Tuesday, or a penny per share, compared with $452 million, or 48 cents per share, for the same period last year.
Excluding one-time items, DuPont earned 44 cents per share, compared with 69 cents per share for last year's third quarter.
The results fell short of the average estimate of 46 cents per share, and Dupont's stock slid 4 per cent in premarket trading.
Revenue totalled about $7.4 billion, down 9 per cent from $8.1 billion.
CEO Ellen Kullman said weaker than expected demand in titanium dioxide and photovoltaic markets contributed to the decline.