Marc McNulty, Alex Forsberg, Brett Roulston and Caleb Belter, into an empty net, scored for Prince George (6-7-1). Chase Witala and Troy Bourke each picked up two assists.
Brendan Kichton and Mike Aviani replied for Spokane (9-4-0).
Eric Williams made 31 saves in defeat.
Prince George finished the night 0-for-4 on the power play, while Spokane was 1-for-2 with the man advantage.