- Democrat Tammy Baldwin won a Senate seat in Wisconsin becoming the first openly gay Senator in American history. She claimed victory over her major competitor Tommy Thompson. Thompson had served as governor for four terms. Baldwin received 51.4 per cent of the vote, helping claim a Senate majority for the Democrats.
- In Massachusetts, which reports pegged as the most expensive Senate seat race, Democrat Elizabeth Warren ousted Senator Scott Brown. Warren, who is best known for her work during the Wall Street bail out, became the first woman elected to the U.S. Senate in Massachusetts, according to reports. She received nearly 54 per cent of the vote in the race between just the two candidates.
- Todd Akin lost the Senate race in Missouri. He received nearly 40 per cent of the vote, but Democrat Claire McCaskill's 54.7 per cent won her the seat. Akin came under fire earlier in the race after making highly controversial comments about rape. Akin said that women's bodies can prevent pregnancies in cases of "legitimate rape."
- Richard Mourdock, another Republican Senate candidate criticized over rape comments, lost the race in Indiana to Democrat Joe Donnelly. During a live television broadcast, Mourdock said pregnancy resulting from rape is "something God intended." Mourdock received 44.4 per cent of the vote, but Donnelly netted almost half of the voters and earned the Senate seat.