Nichols came on in relief of Kerry Joseph to open the second half and led the Esks to a field goal that cut the deficit to 31-10. But he was hurt on Edmonton's second possession when his leg twisted awkwardly while he was being pulled down.
He left on a cart, his left leg immobilized. Eskimos players surrounded him as doctors worked on the 25-year-old quarterback.
It was the second injury blow for Edmonton, which lost star linebacker J.C. Sherritt prior to the game. A nagging ankle injury saw Sherritt watch from the sidelines in a walking boot.