Sylvain Prud'homme will take the leadership role on March 25.
He replaces current president Alan Huggins, who is returning to the U.S. to serve as Lowe's vice-president of international operations and development.
The home improvement retailer said it chose Prud'homme because of his experience in national and international retail merchandising.
Before serving as the executive vice-president of operations and merchandising for Loblaw, Prud'homme worked for retail giant Wal-Mart and grocers Sobey's and Super C.
"He is a strategic thinker and a humble leader, and will be an outstanding addition to the Canada leadership team," said William Robinson, Lowe's head of international operations and development, in a statement.
Lowe's, which is based in Mooresville, N.C., operates 1,745 stores in North America — with the majority in the United States. There are 34 locations and a distribution centre in Canada.
Last September, the company retreated from an attempt to acquire Quebec-based rival Rona (TSX:RON) through a $1.8-billion deal that was shunned by Rona's board.
Since expanding to Canada in 2007, Lowe's has tried to grow its presence in a competitive market that already includes retail giants Home Depot and Rona.
In November, it hinted that it was still considering an acquisition in Canada but would not name a target company.
Lowe's is the second-largest home improvement retailer in the world and reported sales of US$50.2 billion in fiscal 2011.