The network said the segment will be broadcast Monday on the "Today" show. NBC says the convicted sex offender will give his account of the encounters that landed him in prison and discuss former boss Joe Paterno.
Sandusky is serving a 30- to 60-year prison term after being convicted in June of 45 counts of child sexual abuse.
NBC says Sandusky also will also talk about Mike McQueary, a then-graduate assistant who told Paterno in 2001 he'd seen Sandusky showering with a young boy in a football locker room.
McQueary is pursuing a defamation and whistleblower lawsuit against Penn State.
Calls to Sandusky's lawyers and a prison system spokeswoman weren't immediately returned on Friday.