Boston Leier and Cole Sanford each had a goal and an assist for the seventh-seeded Tigers, who outscored Saskatoon 15-4 in a four-game first-round sweep, while Curtis Valk added a single goal.
Lukas Sutter scored the lone goal for the Blades, who entered the post season as the second seed in the Eastern Conference.
Andrey Makarov turned away 25-of-28 shots in defeat.
Medicine Hat went 1 for 7 on the power play while Saskatoon failed to score on three chances with the man advantage.
Seven 10-minute misconducts were handed out to the two clubs with 20 seconds remaining in the third period.