Pitcher Hiroki Kuroda became the latest Yankees player to get hurt, leaving in the second inning with a 2-0 deficit, four batters after Shane Victorino's line drive bruised the middle finger of his pitching hand.
While the Red Sox under new manager John Farrell are off to their best start since going 5-0 in 1999, New York has been outscored 15-6 and outhit 26-15. The Yankees have failed to hold a lead at any point in their opening two games for the first time since 1998.
Boston burst ahead 6-0 with a four-run third against Cody Eppley, and the Yankees never challenged.
Buchholz (1-0) allowed one run and six hits in seven innings. Joel Hanrahan pitched the ninth for his first save with Boston.
New York said Kuroda (0-1) was being sent for X-rays and other tests.
RANGERS 4, ASTROS 0
HOUSTON (AP) — A day after Yu Darvish came within one out of a perfect game, Alexi Ogando and four Texas relievers shut out Houston again, combining for a five-hitter.
Lance Berkman doubled in a run for the Rangers a day after they blanked the Astros 7-0 behind Darvish's nearly historic gem.
Ogando (1-0) allowed four hits with a career-high 10 strikeouts in 6 1-3 innings. The young and inexperienced Astros have struck out 43 times in their first three games.
It's the most strikeouts a pitching staff has combined for in the first three games of a season in major league history, and the most since Cleveland fanned 42 in the first three of the 1966 season.
Philip Humber (0-1) allowed a run and five hits over 5 2-3 innings in his Astros debut.
RAYS 8, ORIOLES 7
ST. PETERSBURG, Fla. (AP) — Matt Joyce led off the bottom of the ninth inning with a towering home run against Tommy Hunter, giving Tampa Bay the victory.
Shelley Duncan hit a three-run homer and Ben Zobrist had a pair of RBI singles for the Rays, who twice came from behind before wasting a late two-run lead.
Fernando Rodney (1-0) blew a save opportunity by allowing a run for the first time since last Aug. 18. Brian Roberts' RBI double off Rodney in the ninth made it 7-all.
Chris Davis went 4 for 4 for the Orioles, hitting a three-run homer for the second straight day and driving in four runs.
Joyce, who had a bunt single as a pinch hitter in the seventh, won it by homering on a 2-1 pitch from Hunter (0-1).
INDIANS 3, BLUE JAYS 2
TORONTO (AP) — Mark Reynolds hit a tiebreaking home run in the 11th inning for Cleveland.
Reynolds drilled a leadoff shot into the second deck off Sergio Santos (0-1), the fifth Blue Jays reliever.
The homer helped the Indians overcome a blown save by Chris Perez, who surrendered a tying shot by Jose Bautista in the ninth.
The overhauled Blue Jays lost their second straight to begin the season. Toronto's offence has just three runs and nine hits in two games.
Matt Albers (1-0) got one out for the win, and Joe Smith finished for his first save.
WHITE SOX 5, ROYALS 2
CHICAGO (AP) — Adam Dunn hit one of Chicago's four homers, leading Jake Peavy and the White Sox to the victory.
Tyler Flowers, Dayan Viciedo and Alexei Ramirez also connected, and the White Sox made it two straight wins to start the season after dropping 12 of 18 to Kansas City a year ago.
The Royals, full of optimism after posting the majors' best record in spring training, will try to avoid a season-opening sweep Thursday.
Peavy (1-0) allowed an earned run and four hits in six innings. Addison Reed worked the ninth for his second save.
Ervin Santana (0-1) pitched six innings in his Kansas City debut and was charged with four runs and five hits.
TWINS 3, TIGERS 2
MINNEAPOLIS (AP) — Eduardo Escobar's two-run double with one out in the ninth inning lifted Minnesota to the win.
After Joaquin Benoit issued a leadoff walk to Trevor Plouffe, reliever Phil Coke took over. Coke got the first out, but Brian Dozier's single advanced pinch-runner Jamey Carroll to third. Escobar then drove the next pitch from Coke to the deepest part of the park in front of the bullpens in left-centre field.
Both runners scored easily as the rebuilding Twins enjoyed their first on-field celebration of the season. The AL Central champion Tigers began the season without a set closer after Jose Valverde wasn't brought back.
Anibal Sanchez threw five scoreless innings for Detroit. But after a two-up, two-down save on Monday, Coke (0-1) blew his chance in this one.
Glen Perkins (1-0) needed only 10 pitches in a perfect ninth inning for the victory.
ATHLETICS 6, MARINERS 2
OAKLAND, Calif. (AP) — Jed Lowrie and Chris Young hit back-to-back home runs in the seventh inning, helping Tommy Milone and the Oakland Athletics beat the Seattle Mariners.
Nate Freiman had two hits and an RBI in his major league debut as Oakland knocked around Joe Saunders and two relievers after managing just one run and six hits in the first two games of the series. Milone (1-0) allowed a pair of first-inning home runs but settled down to retire 17 of his final 18 batters.
Michael Morse had one of the homers for Seattle, his third in two days. Joe Saunders (0-1) lasted four innings and allowed seven hits with four walks.