UFC president Dana White confirmed the details in a text to The Canadian Press.
The 32-year-old from Montreal has defended his 170-pound mixed martial arts championship eight times since winning it back from Matt (The Terror) Serra at UFC 83 in Montreal in April 2008.
Most recently, St-Pierre (24-2) won a unanimous decision over Nick Diaz in March at UFC 158. The champion has won 11 straight fights dating back to April 2007.
The hard-hitting Hendricks (15-1) has won six in a row since losing to Rick (The Horror) Story in December 2010. His last outing was a unanimous decision over Carlos (Natural Born Killer) Condit at UFC 158.
The November card is expected to be UFC 167 and could serve as an anniversary show. The UFC made its debut on Nov. 12, 1993.
GSP is no stranger to milestones. He beat Thiago Alves on UFC 100 in July 2009.