In comments to the state-run Al-Thawra newspaper, Assad rejected the idea that what has been happening in Syria since more than two years is a revolution. Instead, he insisted it is a conspiracy by Western and some Arab states to destabilize his country.
In the same interview, Assad praised this week's massive protests by Egyptians against their Islamists leader and said the overthrow of President Mohammed Morsi meant the end of "political Islam."
In Syria, more than 93,000 people have been killed since the crisis erupted in March 2011. The conflict began as peaceful protests against Assad's rule, then turned into civil war after some opposition supporters took up arms to fight a brutal government crackdown on dissent. Millions of Syrians have been forced to flee their homes.
Throughout the crisis, Assad has insisted that his government is not faced with a popular rebellion, but a Western-backed conspiracy against Syria, accusing the rebels fighting to topple his regime of being terrorists, Islamic extremists and mercenaries of the oil-rich Arab Gulf states that are allies of the United States.
"The countries that conspire against Syria have used up all their tools and they have nothing left except direct (military) intervention," Assad said in the interview, adding that such an intervention would not happen.
The comments coincided with a meeting of the Western-backed Syrian National Coalition in Istanbul in the second attempt in as many months by Assad's opponents to unify their ranks.
The opposition bloc is mostly made up of exiled politicians with little support from Syrians trying to survive the third summer of conflict in the country that has been devastated by the fighting.
Sarah Karkour, a spokeswoman for the SNC, said that acting leader George Sabra and senior opposition figures Louay Safi and Mustafa Sabbagh are topping the list of candidates for the new leadership, including an interim government.
In late May, the opposition leaders met for more than a week in Istanbul, but failed to elected new leaders or devise a strategy for possible peace talks that the U.S. and Russia have been trying to convene in Geneva.
Assad has repeatedly dismissed his political opponents as foreign-directed exiles who don't represent the people of Syria. He has also shrugged off calls to step down, saying he will serve the rest of his term and could consider running for another one in next year's presidential elections.
The paper, Al-Thawra, also quoted him saying his opponents failed because they tried to bring religion onto the battlefield. Assad insisted he still enjoys the support of the majority of Syrians, who have stood against Islamic radicals who have emerged as the most effective force on the opposition's side.
Members of Syria's Sunni Muslim majority have dominated the rebel ranks, while Assad's regime is mostly made up of Alawaites, an offshoot sect of Shiite Islam.
"Whoever brings religion to use for political or factional interests will fall anywhere in the world," Assad said in the interview, again citing Morsi's overthrow by the military in Egypt.