Seymour Rosenblatt, 83, was last seen on Tuesday at 1:45 p.m. near Eglinton Avenue East and Brentcliffe Road. He may be driving a brown 2008 Lexus, with the licence plate BEFA 638.
He is described as white, five feet and six inches tall, 135 pounds, and with grey hair and brown eyes. He was last seen wearing a beige shirt, a rust-coloured jacket, blue jeans and prescription glasses.
Police say they are concerned for his safety and well-being.
Anyone with information is asked to call 33 Division at (416) 808-3300) or Crime Stoppers at (416) 222-TIPS (8477).