Police say the two men, aged 19 and 25, have severe burns to their upper body, arms, hands, head and face, and both remain in serious condition at a Coquitlam hospital.
A white van apparently rear ended an SUV on Monday, mounted the curb of the south Vancouver street, crashed into a wall and caught fire.
Police say two men were seen fleeing the scene, and as fire crews attempted to put out the flames, several explosions occurred.
Officers are looking for the owner of the van, which they now say did not contain contraband drugs but was illegally carrying large amounts of gasoline.
The two occupants of the SUV were treated for minor injuries and released from hospital.