The collision closed the highway early Tuesday morning in Langley at 232nd Street, although a detour is in effect.
Two of the three eastbound lanes are not expected to reopen for several hours.
Sgt. Peter Thiessen confirmed the fatality in a tweet just after 7:30 a.m., but did not release any further details of the accident.
Heavy fog has made the morning commute treacherous in many parts of Metro Vancouver.
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