First-line left-winger Taylor Hall will be sidelined four weeks with an injured left knee suffered in Saturday’s 3-1 win over Ottawa.
"He's a big part of our team, so it's tough to see him get injured," Oilers forward Jordan Eberle said of his teammate to reporters.
Ryan Jones, who was a healthy scratch against the Senators, will take Hall’s spot in the lineup for Tuesday’s game at Montreal (7:30 p.m. ET).
Hall, who had 50 points in 45 games in last year's lockout-shortened season, is no stranger to injuries in his three-plus NHL seasons.
The 21-year-old has rolled an ankle in a fight, been stepped on during a pre-game warmup, had a concussion and required shoulder surgery.
"He's definitely had some tough luck with a skate to the head and a few other things, but he recovers quick and he works his hardest to get back."
The Oilers, who complete a six-game road trip Tuesday, are also without forwards Sam Gagner, Jesse Joensuu, Ryan Hamilton and Steve MacIntyre.
But there is still an abundance of young talent at the forward position with Ryan Nugent-Hopkins, Nail Yakupov, Alex Hemsky, David Perron and Eberle.
"The game doesn't change," said Hemsky, who has five points in nine games this season but a team-worst minus-9. "It doesn't matter if Hallsy's in or Hallsy's out. It's definitely a big loss but I think we have good depth."