The Wednesday night crash involved a Dodge Neon and a Jeep on the city's busy 17 Avenue.
Emergency officials say a man and a woman who were passengers in the Neon died at the scene, while a third passenger died in hospital.
The driver of the car is in serious condition, while four women who were in the Jeep were treated for minor injuries.
Witnesses say they heard a commotion and screeching tires before the crash.
Duty Staff Sgt. Paul Wozney says police believe the car crossed the double-centre line before the collision.
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