The Stampeders confirmed the death Saturday. The team didn't provide details.
Harrison — called "Ham Hands" — played for Calgary from 1964-72, helping the Stampeders win the 1971 Grey Cup title. Inducted into the Canadian Football Hall of Fame in 1993, he was a three-time CFL All-Star.
"The entire organization mourns the death of Herm Harrison," Stampeders President Gordon Norrie said in a statement. "He was a great player on the field for the red and white and an even better person off it. He will be sorely missed and we extend our condolences to his family and friends."
Harrison had three 1,000-yard seasons and finished his nine-year career with 443 receptions for 6,703 yards and 43 touchdowns. He had a team-record four touchdowns catches in a 1970 game against Winnipeg.