The Saskatchewan Roughriders face the Hamilton Tiger-Cats in this year's game, which will be played Sunday at Mosaic Stadium.
The B.C. Lions had home-field advantage in their 2011 victory over Winnipeg before the Toronto Argonauts upended the Calgary Stampeders in last year's finale at Rogers Centre.
Saskatchewan advanced to the Grey Cup game with a convincing 35-13 win over the Calgary Stampeders in the West Division final Sunday. Hamilton punched its ticket with a 36-24 win over Toronto earlier.
This will mark the third time Saskatchewan has hosted the Grey Cup but just the first occasion the Riders will play in the big game at Mosaic Stadium. The Baltimore Stallions won the Cup at Regina in 1995 while the Edmonton Eskimos took it there in 2003.
The Riders last won the Grey Cup in '07 but were finalists in '09 and '10.
To bolster a Grey Cup run on home soil, the Riders acquired veteran slotback Geroy Simon from the B.C. Lions, then added defensive end Ricky Foley and cornerback Dwight Anderson as free agents in the off-season.
Saskatchewan finished the regular season second in the West Division standings with an 11-7 record before downing B.C. 29-25 in the conference semifinal. The Riders then shocked Calgary, which had posted a CFL-best 14-4 record.
The Grey Cup will be a homecoming of sorts for Ticats head coach Kent Austin, quarterback Henry Burris and Andy Fantuz.
Austin led Saskatchewan to the '89 Grey Cup as the club's starting quarterback before winning the '07 crown as the club's head coach. Both Burris and Fantuz are former Riders players.
Hamilton will make its first Grey Cup appearance since 1999 when it beat Calgary at B.C. Place under late coach Ron Lancaster.
The Ticats entered the season with a new coach in Austin, a roster stocked with a lot of young players and a temporary home in Guelph, Ont., while a new stadium was being built in Hamilton.
But the Ticats exceeded expectations and head to Regina on a roll, having won 11 of its last 15 games. However, Saskatchewan won the season series 2-0 and is expected to be the clear favourite in Sunday's game.