RCMP closed westbound lanes of the Trans-Canada Highway near Strathmore after trucks and cars collided or skidded off of the road.
Highway 2 between Didsbury and Carstairs is blocked due to a multi-vehicle collision.
RCMP are also investigating a serious multi-vehicle crash east of Edmonton on the Yellowhead Highway.
The storm prompted airlines to cancel or delay dozens of flights out of Calgary International Airport and delay flights out of Edmonton.
The weather system is forecast to roll through parts of southwestern Saskatchewan.