Police say a man in his 30s was fatally injured outside a downtown convenience store early Tuesday evening.
Hours later, officers were called to a south-side motel where a 26-year-old man had been wounded in a parking lot.
Both victims died in hospital.
The third stabbing happened in a central-area neighbourhood and also involved a man, but he's expected to survive despite suffering critical injuries.
Suspects are being sought in all three cases. (CHED)
Note to readers: This is a corrected story. An earlier version said the man in his 30s was injured early Wednesday evening.