Plaster Rock Fire Chief Tim Corbin confirmed the derailment happened Tuesday evening.
Alexis Fenner, mayor of Plaster Rock, said the derailment is about five kilometres outside the town. She said the roads around the scene have been blocked off and there is no access.
She said three different fire departments have responded.
Fenner said she's not sure whether there is a fire or any danger.
A woman who lives in nearby Wapske, N.B., said she was asked to evacuate her home, located about two kilometres away. She said she can't see any fire from her house. She said there are about eight homes located near the site.