Investigators said Saturday the burglary happened sometime earlier in the week at Jackson's home in South Philadelphia, not far from the team's practice facility.
Police say the cash and jewelry was taken from a safe. A silver 9mm handgun is also missing.
No arrests have been made. A police spokeswoman says the investigation is ongoing.
Jackson was the Eagles' leading receiver this season with 82 catches for 1,332 yards and nine touchdowns. He signed a five-year, $51 million contract before the 2012 season.