Police say the truck was seen weaving and speeding on the city's Yellowhead Trail late Tuesday evening.
A police helicopter directed officers on the ground to an intersection where they tried to stop the vehicle, but it's alleged the driver took a run at a cruiser to get away.
Two officers who feared for their safety fired at the pickup, striking the truck several times, but neither of the two people inside was hurt.
The truck was eventually stopped and a 46-year-old man and a 30-year old woman were arrested.
Police say charges are pending.
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