Thursday's announcement at the Canadian International AutoShow marks the second time that Mazda Canada has earned the overall car of the year title, after winning the award in 2004 for the Mazda3.
The Mazda6 was also the winner of the category Best New Family Car Over $30,000.
Twelve category winners were eligible for the top honours of either the Canadian Car of the Year or Canadian Utility Vehicle of the Year.
Chrysler's Jeep Cherokee was crowned utility vehicle of the year, beating out 18 other SUVs.
Mazda Canada President Kory Koreeda says the company is honoured with the car of the year title, calling the Mazda6 the company's flagship car.
"This car introduced a combination of style, safety, fuel economy, and dynamic driving into the midsize segment that has never been available before," Koreeda said.
The winners are voted on by a group of Canadian automotive journalists, who gathered in Niagara Falls, Ont., last October for a five-day test-drive evaluation of brand-new or significantly changed vehicle models.