That's three more than the 15 deaths reported during the 2009 H1N1 pandemic.
Health officials say the deaths occurred in late December and mid-January, but it took time to confirm that they were flu-related.
Officials also say there have been more than 1,300 lab confirmed cases of flu this year in Saskatchewan and 67 people have been admitted to intensive care.
Dr. Denise Werker, the province's deputy medical health officer, said at the end of January that the flu season has probably peaked in Saskatchewan.
But Werker also cautioned that there can sometimes be a second wave.