Team president Russ Brandon announced Wilson's death at the league's annual meeting, according to NFL.com.
Wilson has owned the Bills since 1959 and was elected to the Pro Football Hall of Fame in 2009.
He was one of the original founders of the American Football League, along with Lamar Hunt and Bud Adams.
There's no immediate word on the cause of death, although Wilson had been in failing health for several years.
More to come