After spending two days in Nova Scotia and Prince Edward Island, the couple departed for Winnipeg on Tuesday afternoon and arrived shortly before 6 p.m. CT.
They are to be greeted by Lt. Gov. Philip Lee and his wife, Anita Lee, as well as Manitoba Premier Greg Selinger, Winnipeg Mayor Sam Katz, and several federal and provincial politicians.
The royal couple will attend an hour-long reception at Government House, where they will meet guests like Wayne Gretzky and Jennifer Jones, whose curling team won gold at the Olympics in Sochi, Russia.
Charles and Camilla will also meet young people and members of the city's business, arts, philanthropy and aboriginal communities.
Grand Chief Derek Nepinak of the Assembly of Manitoba Chiefs says he looks forward to meeting Prince Charles, who he sees as a friend to First Nations.
"I would have to look at him as an ally, recognizing that we came together in a treaty based relationship with the Crown, and that's who represents it here, you know, as he makes his way through his Canadian visit," Nepinak said.
Global spotlight on Winnipeg
The visit will shine a global spotlight on Winnipeg, according to Darcie von Axelstierna with the Manitoba branch of the Monarchist League of Canada.
“There will be media from all over the world covering his visit and Manitoba will become known to some people that hadn't heard of it before.”
Though the visit is just 27 hours, the royal couple will cover a lot of ground.
On Wednesday morning, the couple will be joined by Prime Minister Stephen Harper and his wife, Laureen, as they meet with young people at Aerospace and Aviation in Manitoba Day and tour the Stevenson Hangar at Red River College.
Charles will then attend theAssiniboine Park Zoo to feed Hudson, one of the polar bears at the zoo's Journey to Churchill exhibit, with a special pair of feeding tongs.
"How could it not be the highlight of his life? What better thing can a prince do than feed a polar bear?" said Brian Joseph, the zoo's director of zoological operations.
Camilla will tour the Royal Winnipeg Ballet, while the Prince of Wales will visit Place Bernadette Poirier for a reception marking the opening of the facility.
Then on Wednesday afternoon, The Fort Garry Horse army reserve will be giving Prince Charles six "Winnie the Bear" dolls clad in military uniforms at the Assiniboine Park Conservatory. Charles will also take in the Winnie the Pooh Gallery at the Pavilion Gallery Museum.
Together, the royal pair will attend a reception at Government House and take part in an Order of Manitoba ceremony at the Manitoba Legislature where the Prince of Wales will make a speech.
Winnipeg is the royal couple's final stop on their three-province tour.