Police say the collision occurred on Danforth Road at Mackinac Crescent, a few blocks south of Lawrence Avenue East.
An Infiniti G35 was heading southbound, came to a stop and was “attempting to reverse into a driveway,” according to a news release.
A southbound Yamaha motorcycle ended up striking the back of the car.
The motorcycle driver suffered life threatening injuries and was taken to hospital.
The collision remains under investigation. Anyone with information is asked to contact investigators at 416-808-1900. Information can also be passed on anonymously through Crime Stoppers at 416-222-8477.