They replace a quartet of pitchers who started Sunday: the Giants' Madison Bumgarner, the Reds' Johnny Cueto, the Padres' Tyson Ross and the Atlanta Braves' Julio Teheran.
Hudson, a four-time All-Star, is 7-6 with a 2.87 ERA, and Simon is 12-3 with a 2.70 ERA. Street has 24 saves and a 1.09 ERA, and Clippard is 6-2 with a 2.03 ERA in 43 relief appearances.
"It's a give and take. Obviously, I'm honoured and happy in that sense," Clippard said before laughing and adding, "I'd like to go get some rounds of golf in, but I'll take one for the team."