The low-profile, 36-year-old French designer will replace Christophe Lemaire, whose departure was announced earlier this week and who will take his final bow in October.
Though Vanhee-Cybulski is not a big name, she was previously women's design director at Ashley Olsen and Mary-Kate Olsen's The Row, and has worked in important behind-the-scenes roles at Martin Margiela and Celine in Paris.
She said Thursday in a statement she was "overjoyed to join the Hermes house, which I admire and share all my values with."
Hermes head Axel Dumas, meanwhile, sang her praises, saying that "her talent and creative process will be assets in developing female ready-to-wear."
Vanhee-Cybulski will show her first collection in March 2015.